In-Vitro Toxicology & Cellular Function Testing
A comprehensive biological safety assessment requires understanding not only whether a material is toxic, but how it influences cellular function and biological pathways. In-Vitro Toxicology & Cellular Function Testing evaluates cellular responses such as viability, apoptosis, inflammation, oxidative stress, proliferation, differentiation, and metabolic activity following exposure to materials, extracts, or chemical leachables.
At Materials Metric, these studies provide mechanistic insight beyond basic cytotoxicity, helping identify sub-lethal effects and functional disturbances that may impact long-term safety and performance. Conducted under controlled, reproducible conditions and aligned with ISO and FDA expectations, in-vitro toxicology testing supports material screening, biological risk assessment, and informed progression toward advanced in-vivo studies and regulatory submissions.
Uses
• Screening materials for deeper biological compatibility
• Comparing coatings, treatments, or formulations
• Investigating causes of cytotoxicity or irritation
• Mechanistic toxicology for innovative materials
Applications
• Hydrogels, elastomers, composites
• Bioactive coatings
• Nanomaterials
• Regenerative medicine scaffolds
Sample Analysis Process
• Cell exposure using 2D or 3D culture systems
• Quantitative functional assays
• Gene/protein expression
• Oxidative stress and inflammatory marker analysis
Why Choose Materials Metric
Materials Metric provides mechanistic in-vitro toxicology grounded in advanced cell biology, enabling deeper insight into biocompatibility than routine cytotoxicity alone.
We offer:
- Broad assay portfolio (viability, inflammation, oxidative stress, apoptosis, proliferation, differentiation)
- ISO 9001:2015 accredited processes for consistent, traceable cellular data
- Biomaterials-focused scientific expertise to interpret complex cellular responses
- Correlative analysis linking chemical composition to biological effects
- Regulatory-aligned documentation that strengthens biological safety narratives
Materials Metric gives you high-resolution biological understanding essential for R&D, troubleshooting, and regulatory submissions.
Related services