High-Performance Liquid Chromatography (HPLC)
High-Performance Liquid Chromatography (HPLC) is a separation and quantification technique used to analyze components in liquid samples by driving a solution through a chromatographic column under high pressure. It enables precise identification and measurement of target compounds, supporting accurate assessment of purity, concentration, impurities, and degradation products. At Materials Metric, we apply HPLC using validated, application-specific methods to support polymers, pharmaceuticals, biomolecules, additives, and complex chemical formulations. Our chromatographic workflows deliver reproducible retention profiles and reliable quantitative data, supporting research, formulation development, quality control, stability studies, and regulatory documentation.
Use of HPLC
โข Quantification of active compounds
โข Detection of impurities and residual monomers
โข Polymer degradation and additive analysis
โข Drug release and stability studies
โข Leachables and extractables analysis
Applications of HPLC
โข Pharmaceuticals: potency, impurity profiling
โข Polymers: monomer residuals, stabilizers, degradation products
โข Biomaterials: hydrogel degradation, release studies
โข Food & Chemicals: ingredient verification
Sample Analysis Process
1. Submission & Review
- Identify analytes, solvents, and detection needs
2. Sample Preparation
- Filtration, dilution, or extraction
3. HPLC Measurement
- UV, fluorescence, or mass spectrometry detection
- Custom gradient and isocratic runs
4. Reporting
- Chromatograms
- Quantification curves
- Impurity profiles
Why Choose Materials Metric for Your HPLC Analysis
โข Accurate quantification and trace-level detection
โข Specialized expertise in complex polymer and pharmaceutical samples
โข Multiple detection modes (UV, fluorescence, MS)
โข Support for extractables, leachables, and stability studies
โข Clear reporting with quantitative results and interpretation
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